PUBLICATIONS

2026 – 2021| 2020 – 2016 | 2015 and earlier

2026

• Smith D. When the Money Stops: A Safety-First Plan for Paused Clinical Trials. Clin Transl Sci. 2026 Jan;19(1):e70465. doi: 10.1111/cts.70465. PMID: 41451898; PMCID: PMC12741915.

2025

• “UC San Diego scientist weighs in on the state of research after federal cuts and banned words“.  2025 inewsource.org 
• George AF, Neidleman J, Luo X, Frouard J, Elphick N, Yin K, Young KC, Ma T, Andrew AK, Ezeonwumelu IJ, Pedersen JG, Chaillon A, Porrachia M, Woodworth B, Jakobsen MR, Thomas R, Smith DM, Gianella S, Roan NR. Anatomical, subset, and HIV-dependent expression of viral sensors and restriction factors. Cell Rep. 2025 Jan 28;44(1):115202. doi: 10.1016/j.celrep.2024.115202. Epub 2025 Jan 10. PMID: 39798087; PMCID: PMC11829653.
• Streuli S, Servin AE, Salgin L, Muñoz FA, Smith DM, Stockman JK, O’Bryan SE, Ramirez D, James-Price C, Skaathun B. Chronic conditions, COVID-19 vaccination, and institutional trust among Hispanic/Latinx communities in San Diego, California. Prev Med. 2025 Mar;192:108240. doi: 10.1016/j.ypmed.2025.108240. Epub 2025 Feb 3. PMID: 39909210.
• Grillo MP, Saylors K, Tran BR, Brown N, Tripathi O, Killion J, Macera C, Faye B, Chisoko EC, Kabengele M, Mutombe AM, Djoko CF, Smith D, Chaillon A. Sexual Networks and Behavioral Characteristics of HIV-Positive Male Military Members, Female Sex Workers, and Male Civilians. AIDS Behav. 2025 Mar;29(3):993-1003. doi: 10.1007/s10461-024-04580-z. Epub 2025 Jan 13. PMID: 39806186; PMCID: PMC11830637.
• Bender Ignacio RA, Chew KW, Moser C, Currier JS, Eron JJ, Javan AC, Giganti MJ, Ritz J, Gibbs M, Kouekam HT, Esser MT, Daar ES, Choudhary M, Deo R, Fletcher CV, Li JZ, Hughes MD, Smith D*, Wohl DA; ACTIV-2/A5401 Study Team. Tixagevimab/cilgavimab or placebo for COVID-19 in ACTIV-2: Safety, pharmacokinetics and neutralizing and anti-drug antibodies. iScience. 2025 Feb 4;28(3):111938. doi: 10.1016/j.isci.2025.111938. PMID: 40124489; PMCID: PMC11927737.
• Yeola A, Allen MR, Desai N, Poliak A, Yang KH, Smith DM, Ayers JW. Growing Health Concern Regarding Gambling Addiction in the Age of Sportsbooks. JAMA Intern Med. 2025 Apr 1;185(4):382-389. doi: 10.1001/jamainternmed.2024.8193. PMID: 39960737; PMCID: PMC11833657.
• Deiss R, Gianella S, Dullano C, Solso S, Little SJ, Kaytes A, Taylor J, Riggs PK, Hastie E, Smith D, Dubé K. Navigating the dual role of physician and clinician investigator in end-of-life research. AIDS Care. 2025 Apr;37(4):618-625. doi: 10.1080/09540121.2025.2458629. Epub 2025 Feb 3. PMID: 39899534; PMCID: PMC11955293.
• Mateja A, Chu E, Murray TA, Bramante CT, Moser C, Givens N, Abdelghany M, Blair C, Chen S, Lat PK, Harari O, Kallewaard NL, Macpherson LF, Boulware DR, Suñer C, Mitjà O, Adam SJ, De Gruttola V, Hughes MD, Rubin D, Smith DM*, Potter GE. The Choice of Viral Load End Point in Early Phase Trials of COVID-19 Treatments Aiming to Reduce 28-Day Hospitalization and/or Death. J Infect Dis. 2025 Jul 30;232(1):60-68. doi: 10.1093/infdis/jiaf282. PMID: 40461945; PMCID: PMC12308656.
• Gianella S, Yu T, Wang R, Ignacio C, Schanz M, Kouyos RD, Caballero G, Gaitan NC, Rawlings S, Kuster H, Metzner KJ, Gandhi RT, Li JZ, Günthard HF, Smith DM, Chaillon A. Viral and Immune Risk Factors of HIV Rebound After Interruption of Antiretroviral Therapy. J Infect Dis. 2025 Jun 2;231(5):1221-1229. doi: 10.1093/infdis/jiae585. PMID: 39661441; PMCID: PMC12128076.
• Giganti MJ, Chew KW, Moser C, Eron JJ, Pinilla M, Li JZ, Ritz J, Javan AC, Wohl DA, Daar ES, Currier JS, Smith DM*, Hughes MD; ACTIV-2/A5401 Study Team. Implementation of a seamless phase 2/3 study design in the setting of an emergent infectious disease pandemic: Lessons learned from the ACTIV-2 platform COVID-19 treatment trial. Contemp Clin Trials. 2025 Jun;153:107887. doi: 10.1016/j.cct.2025.107887. Epub 2025 Mar 25. PMID: 40147543; PMCID: PMC12085286.
• Desai KS, Smith DM, Ayers JW. Concerns About Crisis Pregnancy Centers Analysis-Reply. JAMA Intern Med. 2025 Jul 1;185(7):903-904. doi: 10.1001/jamainternmed.2025.0610. PMID: 40354081.
• Luetkemeyer AF, Chew KW, Lacey S, Hughes MD, Harrison LJ, Daar ES, Eron J, Fletcher CV, Greninger AL, Hessinger D, Li JZ, Mailhot D, Wohl D, Chayakulkeeree M, Mendoza JLA, Elistratova P, Makinde O, Morgan G, Portsmouth S, Uehara T, Smith D*, Currier JS. Ensitrelvir for the Treatment of Nonhospitalized Adults with COVID-19: Results from the SCORPIO-HR, Phase 3, Randomized, Double-blind, Placebo-Controlled Trial. Clin Infect Dis. 2025 Jul 18;80(6):1235-1244. doi: 10.1093/cid/ciaf029. PMID: 39960062; PMCID: PMC12272848.
• Smith DM, Rowland EF, Gianella S, Patel SP, Solso S, Dullano C, Deiss R, Wells D, Ignacio C, Caballero G, Porrachia M, Kieffer C, Chaillon A. HIV Integration into the PTEN Gene and Its Tumor Microenvironment Implications for Lung Cancer. Curr Oncol. 2025 Jul 4;32(7):389. doi: 10.3390/curroncol32070389. PMID: 40710199; PMCID: PMC12294024.
• Smith D, Fleming T, Gianella S, Halloran E, Hillier S, Longini I, Smeaton L, DeGruttola V. Salvaging information from paused or stopped clinical studies. Clin Trials. 2025 Jul 12:17407745251353429. doi: 10.1177/17407745251353429. Epub ahead of print. PMID: 40650496; PMCID: PMC12331140.
• Trunfio M, Smith D, Gaitan N, Awad M, Porrachia M, Wells A, Rivera-Nieves J, Hastie E, Riggs P, Gianella S, Chaillon A. HIV Reservoir Dynamics and Bacteriome Composition Along the Gut Axis. J Infect Dis. 2025 Oct 29:jiaf546. doi: 10.1093/infdis/jiaf546. Epub ahead of print. PMID: 41162327.
• Desai KS, Tiyyala VM, Tiyyala P, Yeola A, Gallegos-Rangel A, Montiel-Torres A, Allen MR, Dredze M, Vandrey RG, Thrul J, Leas EC, Hogarth M, Smith DM, Ayers JW. Waldo: Automated discovery of adverse events from unstructured self reports. PLOS Digit Health. 2025 Sep 30;4(9):e0001011. doi: 10.1371/journal.pdig.0001011. PMID: 41026671; PMCID: PMC12483200.
• Deo R, Choudhary MC, Glover OT, Ignacio RB, Boucau J, Chew KW, Moser C, Currier JS, Eron JJ, Javan AC, Giganti MJ, Aga E, Gibbs M, Cohen T, Streicher K, Soboleva K, Fletcher CV, Daar ES, Greninger AL, Coombs RW, Fischer W, Hughes MD, Smith D, Wohl DA, Barczak AK, Li JZ. Rapid Elimination of Culturable SARS-CoV-2 With Intramuscular or Intravenous Administration of Antiviral Monoclonal Antibody Therapy. Open Forum Infect Dis. 2025 Sep 8;12(9):ofaf542. doi: 10.1093/ofid/ofaf542. PMID: 40980587; PMCID: PMC12449731.
• Ahmed A, Taylor J, Tran W, Swaitch S, Ndukwe SO, Lau R, Oliveira KH, Solso S, Dullano C, Kaytes A, Smith D, Deiss R, Gianella S, Dubé K. Motivations, acceptability and ethical considerations for interventional HIV cure research at the end of life: perspectives from long-term survivors of HIV in the United States. BMC Med Ethics. 2025 Aug 23;26(1):112. doi: 10.1186/s12910-025-01253-x. PMID: 40849625; PMCID: PMC12374411.
• Mateja A, Chu E, Murray TA, Bramante CT, Moser C, Givens N, Abdelghany M, Blair C, Chen S, Lat PK, Harari O, Kallewaard NL, Macpherson LF, Boulware DR, Suñer C, Mitjà O, Adam SJ, De Gruttola V, Hughes MD, Rubin D, Smith DM, Potter GE. Evaluating viral load sampling schemes and swabbing methods for optimal surrogacy. J Infect Dis. 2025 Aug 20:jiaf443. doi: 10.1093/infdis/jiaf443. Epub ahead of print. PMID: 40832932.
• Smith DM, Huynh J, Pham B, Porrachia M, Ignacio C, Mudumba S, Kuizon CN, Gianella S, Chaillon A. Insights Gained from the Immune Response and Screening of Healthcare Workers After COVID-19 Vaccination. COVID. 2025; 5(8):129. doi: 10.3390/covid5080129
• Funk M; Patton T; Shrader C-H; Abramovitz D; Almeida A; Goyal R; Han B; Skaathun B; Strathdee S; Smith D; Borquez A. Potential Substance Use Disorder Epidemics Related to Prescription-Drugs in the United States: Development, Validation and Application of a Risk Assessment Approach. Drug and alcohol dependence. Vol.267 p.111540. doi: 10.1016/j.drugalcdep.2024.111540
• Yeung ST, Moar P, Gomez-Moreno V, Smith DM, Chaillon A, Gianella S, Ndhlovu LC. Spatial biology discovery approaches to dissect in situ modification of site-specific tissue HIV reservoirs 2542. The Journal of Immunology, Volume 214, Issue Supplement_1, November 2025, vkaf283.448, doi: 10.1093/jimmun/vkaf283.448.
• Woods V, Umansky T, Russell SM, McGovern BL, Rosales R, Rodriguez ML, van Bakel H, Sordillo EM, Simon V, García-Sastre A, White KM, Brubaker WF, Smith DM, Haders D. MDL-001: An Oral, Safe, and Well-Tolerated Broad-Spectrum Inhibitor of Viral Polymerases. bioRxiv 2025.01. 13.632836. doi: https://doi.org/10.1101/2025.01.13.632836.
• Umansky T, Woods V, Russell SM, Garvey DS, Smith DM, Haders D. GALILEO Generatively Expands Chemical Space and Achieves One-Shot Identification of a Library of Novel, Specific, Next Generation Broad-Spectrum Antiviral Compounds at High Hit Rates. bioRxiv 2025.01. 17.633620. doi: https://doi.org/10.1101/2025.01.17.633620.

2024

• Ndukwe SO, Patel H, Shelton B, Concha-Garcia S, Dullano C, Solso S, Hendrickx S, Riggs PK, Villa TJ, Kaytes A, Taylor J, Little SJ, Lessard D, Arora AK, Costiniuk CT, Eskaf S, Smith DM, Gianella S, Dubé K. People with HIV at the end-of-life and their next-of-kin/loved ones are willing to participate in interventional HIV cure-related research. AIDS. 2024 Feb 1;38(2):235-243. doi: 10.1097/QAD.0000000000003754. Epub 2023 Oct 17. PMID: 37861674.
• Giganti MJ, Chew KW, Eron JJ, Smith DM, Currier JS, Hughes MD. Response to Drs. de Grooth and Parienti. J Infect Dis. 2024 Feb 7:jiae053. doi: 10.1093/infdis/jiae053. Epub ahead of print. PMID: 38324658.
• Ayers JW, Desai N, Smith DM. Regulate Artificial Intelligence in Health Care by Prioritizing Patient Outcomes. JAMA. 2024 Jan 29. doi: 10.1001/jama.2024.0549. Epub ahead of print. PMID: 38285467.
• Li JZ, Melberg M, Kittilson A, Abdel-Mohsen M, Li Y, Aga E, Bosch RJ, Wonderlich ER, Kinslow J, Giron LB, Di Germanio C, Pilkinton M, MacLaren L, Keefer M, Fox L, Barr L, Acosta E, Ananworanich J, Coombs R, Mellors J, Deeks S, Gandhi RT, Busch M, Landay A, Macatangay B, Smith DM; AIDS Clinical Trials Group A5345 Study Team. Predictors of HIV rebound differ by timing of antiretroviral therapy initiation. JCI Insight. 2024 Feb 8;9(3):e173864. doi: 10.1172/jci.insight.173864. PMID: 38329130.
• Skaathun B, Salgin L, Muñoz FA, Talavera GA, Smith DM, Stockman JK, O’Bryan SE, Ramirez D, James-Price C, Servin AE. Study protocol: Project 2VIDA! SARS-CoV-2 vaccine intervention delivery for adults in Southern California. Front Public Health. 2024 Mar 14;12:1291332. doi: 10.3389/fpubh.2024.1291332. PMID: 38550328; PMCID: PMC10977100.
• Ayers JW, Poliak A, Beros NT, Paul M, Dredze M, Hogarth M, Smith DM. A Digital Cohort Approach for Social Media Monitoring: A Cohort Study of People Who Vape E-Cigarettes. Am J Prev Med. 2024 Mar 16:S0749-3797(24)00028-X. doi: 10.1016/j.amepre.2024.01.016. Epub ahead of print. PMID: 38904592.
• O’Bryan SE, Muñoz F, Smith D, Bearse A, Melendrez B, Kamdar B, James-Price C, Ramirez D, Servin AE. Community based participatory research as a promising practice for addressing vaccine hesitancy, rebuilding trust and addressing health disparities among racial and ethnic minority communities. Hum Vaccin Immunother. 2024 Dec 31;20(1):2326781. doi: 10.1080/21645515.2024.2326781. Epub 2024 Mar 18. PMID: 38497273; PMCID: PMC10950264.
• Phan T, Zitzmann C, Chew KW, Smith DM, Daar ES, Wohl DA, Eron JJ, Currier JS, Hughes MD, Choudhary MC, Deo R, Li JZ, Ribeiro RM, Ke R, Perelson AS; ACTIV-2/A5401 Study Team. Modeling the emergence of viral resistance for SARS-CoV-2 during treatment with an anti-spike monoclonal antibody. PLoS Pathog. 2024 Apr 18;20(4):e1011680. doi: 10.1371/journal.ppat.1011680. PMID: 38635853; PMCID: PMC11060554.
• Choudhary MC, Deo R, Evering TH, Chew KW, Giganti MJ, Moser C, Ritz J, Regan J, Flynn JP, Crain CR, Wohl DA, Currier JS, Eron JJ, Margolis D, Zhu Q, Zhon L, Ya L, Greninger AL, Hughes MD, Smith D, Daar ES, Li JZ; ACTIV-2/A5401 Study Team. Characterization of treatment resistance and viral kinetics in the setting of single- versus dual-active monoclonal antibodies against SARS-CoV-2. J Infect Dis. 2024 May 8:jiae192. doi: 10.1093/infdis/jiae192. Epub ahead of print. PMID: 38716969.
• Saravanan S, Shankar EM, Vignesh R, Ganesh PS, Sankar S, Velu V, Smith DM, Balakrishnan P, Viswanathan D, Govindasamy R, Venkateswaran AR. Occult hepatitis B virus infection and current perspectives on global WHO 2030 eradication. J Viral Hepat. 2024 Apr 5. doi: 10.1111/jvh.13928. Epub ahead of print. PMID: 38578122.
• Carrasco-Hernández R, Valenzuela-Ponce H, Soto-Nava M, García-Morales C, Matías-Florentino M, Wertheim JO, Smith DM, Reyes-Terán G, Ávila-Ríos S. Unveiling ecological/evolutionary insights in HIV viral load dynamics: Allowing random slopes to observe correlational changes to CpG-contents and other molecular and clinical predictors. Epidemics. 2024 Jun;47:100770. doi: 10.1016/j.epidem.2024.100770. Epub 2024 May 14. PMID: 38761432; PMCID: PMC11213286.
• Allen MR, Desai N, Namazi A, Leas E, Dredze M, Smith DM, Ayers JW. Characteristics of X (Formerly Twitter) Community Notes Addressing COVID-19 Vaccine Misinformation. JAMA. 2024 May 21;331(19):1670-1672. doi: 10.1001/jama.2024.4800. PMID: 38656757; PMCID: PMC11044002.
• Leas EC, Ayers JW, Desai N, Dredze M, Hogarth M, Smith DM. Using Large Language Models to Support Content Analysis: A Case Study of ChatGPT for Adverse Event Detection. J Med Internet Res. 2024 May 2;26:e52499. doi: 10.2196/52499. PMID: 38696245; PMCID: PMC11099800.
• Corado KC, Chew KW, Giganti MJ, Mu Y, Fletcher CV, Currier JS, Daar ES, Wohl DA, Li JZ, Moser CB, Ritz J, Javan AC, Neytman G, Caskey M, Hughes MD, Smith DM*, Eron JJ*; ACTIV-2/A5401 Study Team. Safety, Efficacy, and Pharmacokinetics of Combination SARS-CoV-2 Neutralizing Monoclonal Antibodies BMS-986414 (C135-LS) and BMS-986413 (C144-LS) Administered Subcutaneously in Non-Hospitalized Persons with COVID-19 in a Phase 2 Trial. Pathog Immun. 2024 May 6;9(1):138-155. doi: 10.20411/pai.v9i1.660. PMID: 38746756; PMCID: PMC11093219.
• Gianella S, Anderson C, Chaillon A, Wells A, Porrachia M, Caballero G, Meneses M, Lonergan J, Woodworth B, Gaitan NC, Rawlings SA, Muttera L, Harkness L, Little SJ, May S, Smith D. Impact of influenza and pneumococcal vaccines on HIV persistence and immune dynamics during suppressive antiretroviral therapy. AIDS. 2024 Jul 1;38(8):1131-1140. doi: 10.1097/QAD.0000000000003882. Epub 2024 Mar 22. PMID: 38526550; PMCID: PMC11141237.
• Schlachetzki JC, Gianella S, Ouyang Z, Lana AJ, Yang X, O’Brien S, Challacombe JF, Gaskill PJ, Jordan-Sciutto KL, Chaillon A, Moore D, Achim CL, Ellis RJ, Smith DM, Glass CK. Gene expression and chromatin conformation of microglia in virally suppressed people with HIV. Life Sci Alliance. 2024 Jul 26;7(10):e202402736. doi: 10.26508/lsa.202402736. PMID: 39060113; PMCID: PMC11282357.
• Bloom N, Ramirez SI, Cohn H, Parikh UM, Heaps A, Sieg SF, Greninger A, Ritz J, Moser C, Eron JJ, Bajic G, Currier JS, Klekotka P, Wohl DA, Daar ES, Li J, Hughes MD, Chew KW, Smith DM, Crotty S, Coelho CH; Accelerating COVID-19 Therapeutic Interventions and Vaccines–2/A5401 (ACTIV-2/A5401) Study Team. SARS-CoV-2 Monoclonal Antibody Treatment Followed by Vaccination Shifts Human Memory B-Cell Epitope Recognition, Suggesting Antibody Feedback. J Infect Dis. 2024 Nov 15;230(5):1187-1196. doi: 10.1093/infdis/jiae371. PMID: 39036987; PMCID: PMC11566236.
• Evering TH, Moser C, Jilg N, Ritz J, Wohl DA, Li JZ, Margolis D, Javan AC, Eron JJ, Currier JS, Daar ES, Smith DM, Hughes MD, Chew KW; ACTIV-2/A5401 Study Team. Post-acute COVID-19 outcomes including participant-reported long COVID: amubarvimab/romlusevimab versus placebo in the ACTIV-2 trial. EClinicalMedicine. 2024 Aug 16;75:102787. doi: 10.1016/j.eclinm.2024.102787. PMID: 39252866; PMCID: PMC11381616.
• Ramirez SI, Lopez PG, Faraji F, Parikh UM, Heaps A, Ritz J, Moser C, Eron JJ, Wohl DA, Currier JS, Daar ES, Greninger AL, Klekotka P, Grifoni A, Weiskopf D, Sette A, Peters B, Hughes MD, Chew KW, Smith DM, Crotty S; ACTIV-2/A5401 Study Team. Early antiviral CD4 and CD8 T cell responses and antibodies are associated with upper respiratory tract clearance of SARS-CoV-2. bioRxiv [Preprint]. 2024 Aug 19:2023.10.25.564014. doi: 10.1101/2023.10.25.564014. Update in: JCI Insight. 2024 Dec 20;9(24):e186078. doi: 10.1172/jci.insight.186078. PMID: 37961119; PMCID: PMC10634820.
• Soto F, Servin AE, Smith DM, Muñoz F, Aldous JL, Stockman JK, Ramirez D, Skaathun B. Generational Factors Associated with SARS-CoV-2 Vaccine Completion for Americans of Mexican Decent Living along the United States-Mexico Border Region. Vaccines (Basel). 2024 Oct 3;12(10):1137. doi: 10.3390/vaccines12101137. PMID: 39460304; PMCID: PMC11511094.
• Jilg N, Giganti MJ, Chew KW, Shaw-Saliba K, Ritz J, Moser C, Evering TH, Daar ES, Eron JJ, Currier JS, Hughes MD, Lane HC, Dewar R, Smith DM*, Li JZ. Severe Acute Respiratory Syndrome Coronavirus 2 Plasma Antibody and Nucleocapsid Antigen Status Predict Outcomes in Outpatients With Coronavirus Disease 2019. Clin Infect Dis. 2024 Jul 17:ciae324. doi: 10.1093/cid/ciae324. Epub ahead of print. PMID: 39018444.
• Chew KW, Taiwo BO, Moser C, Daar ES, Wohl DA, Ritz J, Javan AC, Li JZ, Fischer W, Greninger AL, Bausch C, Luke T, Call R, Neytman G, Giganti MJ, Fletcher CV, Hughes MD, Eron JJ, Currier JS, Smith DM; ACTIV-2/A5401 Study Team. Safety and Efficacy of SAB-185 for Non-hospitalized Adults with COVID-19: A Randomized Clinical Trial. J Infect Dis. 2024 Jul 20:jiae369. doi: 10.1093/infdis/jiae369. Epub ahead of print. PMID: 39028902.
• Leibel SL, McVicar RN, Murad R, Kwong EM, Clark AE, Alvarado A, Grimmig BA, Nuryyev R, Young RE, Lee JC, Peng W, Zhu YP, Griffis E, Nowell CJ, James B, Alarcon S, Malhotra A, Gearing LJ, Hertzog PJ, Galapate CM, Galenkamp KMO, Commisso C, Smith DM, Sun X, Carlin AF, Sidman RL, Croker BA, Snyder EY. A therapy for suppressing canonical and noncanonical SARS-CoV-2 viral entry and an intrinsic intrapulmonary inflammatory response. Proc Natl Acad Sci U S A. 2024 Jul 23;121(30):e2408109121. doi: 10.1073/pnas.2408109121. Epub 2024 Jul 19. PMID: 39028694; PMCID: PMC11287264.
• Parikh UM, Heaps AL, Moisi D, Gordon KC, Mellors JW, Choudhary MC, Deo R, Moser C, Klekotka P, Landay AL, Currier JS, Eron JJ, Chew KW, Smith DM, Li JZ, Sieg SF; Team ACTIV-2/A5401 Study. Comparison Study of the Bio-Plex and Meso Scale Multiplexed SARS-CoV-2 Serology Assays Reveals Evidence of Diminished Host Antibody Responses to SARS-CoV-2 after Monoclonal Antibody Treatment. Pathog Immun. 2024 Aug 15;9(2):58-78. doi: 10.20411/pai.v9i2.715. PMID: 39165724; PMCID: PMC11335343.
• Paul MK, Choudhary MC, Heaps AL, Deo R, Moisi D, Gordon KC, Mellors JW, Moser C, Klekotka P, Landay A, Currier JS, Eron JJ, Chew KW, Smith DM, Sieg SF, Parikh UM, Li JZ; ACTIV-2/A5401 Study Team. Impact of SARS-CoV-2 Resistance to Antiviral Monoclonal Antibody Therapy on Neutralizing Antibody Response. Pathog Immun. 2024 Aug 21;9(2):79-93. doi: 10.20411/pai.v9i2.718. PMID: 39247686; PMCID: PMC11378757.
• Chew KW, McGinley B, Moser C, Li JZ, Evering TH, Ritz J, Javan AC, Margolis D, Wohl DA, Hughes MD, Daar ES, Currier JS, Eron JJ, Smith DM; ACTIV-2/A5401 Study Team. Viral and symptom rebound following anti-SARS-CoV-2 monoclonal antibody therapy in a randomized placebo-controlled trial. J Infect Dis. 2024 Oct 14:jiae501. doi: 10.1093/infdis/jiae501. Epub ahead of print. PMID: 39400063.
• Oh MA, Currier J, Khan A, Mylonakis E, Newell M, Ignacio RB, Jilg N, Safdar B, Merck LH, Smith DM. Lessons learned from COVID-19 to overcome challenges in conducting outpatient clinical trials to find safe and effective therapeutics for the next infectious pandemic. J Clin Transl Sci. 2024 Oct 15;8(1):e153. doi: 10.1017/cts.2024.607. PMID: 39540115; PMCID: PMC11557272.
• Schlachetzki JC, Gianella S, Ouyang Z, Lana AJ, Yang X, O’Brien S, Challacombe JF, Gaskill PJ, Jordan-Sciutto KL, Chaillon A, Moore D, Achim CL, Ellis RJ, Smith DM, Glass CK. Correction: Gene expression and chromatin conformation of microglia in virally suppressed people with HIV. Life Sci Alliance. 2024 Oct 28;8(1):e202403085. doi: 10.26508/lsa.202403085. Erratum for: Life Sci Alliance. 2024 Jul 26;7(10):e202402736. doi: 10.26508/lsa.202402736. PMID: 39467638; PMCID: PMC11519389.
• Yu T, Wu L, Bosch RJ, Smith DM, Wang R. Fast standard error estimation for joint models of longitudinal and time-to-event data based on stochastic EM algorithms. Biostatistics. 2024 Nov 11:kxae043. doi: 10.1093/biostatistics/kxae043. Epub ahead of print. PMID: 39523821.
• Ramirez SI, Lopez PG, Faraji F, Parikh UM, Heaps A, Ritz J, Moser C, Eron JJ, Wohl D, Currier J, Daar ES, Greninger A, Klekotka P, Grifoni A, Weiskopf D, Sette A, Peters B, Hughes MD, Chew KW, Smith DM*, Crotty S*; Accelerating COVID-19 Therapeutic Interventions-2 (ACTIV-2)/A5401 Study Team. Early antiviral CD4+ and CD8+ T cells are associated with upper airway clearance of SARS-CoV-2. JCI Insight. 2024 Dec 20;9(24):e186078. doi: 10.1172/jci.insight.186078. PMID: 39704169; PMCID: PMC11665554.
• Gianella S, Yu T, Wang R, Ignacio C, Schanz M, Kouyos RD, Caballero G, Gaitan N, Rawlings S, Kuster H, Metzner KJ, Gandhi RT, Li JZ, Günthard H, Smith DM, Chaillon A. Viral and Immune Risk Factors of HIV Rebound after Interruption of Antiretroviral Therapy. J Infect Dis. 2024 Dec 11:jiae585. doi: 10.1093/infdis/jiae585. Epub ahead of print. PMID: 39661441.
• Magombedze G, Vendrame E, SenGupta D, Geleziunas R, Little S, Smith D, Walker B, Routy JP, Hecht FM, Chun TW, Sneller M, Li JZ, Deeks SG, Peluso MJ. Early Viral Dynamics Predict HIV Post-Treatment Control After Analytic Treatment Interruption. J Infect Dis. 2024 Nov 8:jiae551. doi: 10.1093/infdis/jiae551. Epub ahead of print. PMID: 39513745.
• Desai KS, Keene H, Dredze M, Smith DM, Ayers JW. Characterizing Services Advertised on Crisis Pregnancy Center Websites. JAMA Intern Med. 2024 Dec 2:e246440. doi: 10.1001/jamainternmed.2024.6440. Epub ahead of print. PMID: 39621321; PMCID: PMC11612908.
• Gandhi RT, Landovitz RJ, Sax PE, Smith DM, Springer SA, Günthard HF, Thompson MA, Bedimo RJ, Benson CA, Buchbinder SP, Crabtree-Ramirez BE, Del Rio C, Eaton EF, Eron JJ Jr, Hoy JF, Lehmann C, Molina JM, Jacobsen DM, Saag MS. Antiretroviral Drugs for Treatment and Prevention of HIV in Adults: 2024 Recommendations of the International Antiviral Society-USA Panel. JAMA. 2024 Dec 1. doi: 10.1001/jama.2024.24543. Epub ahead of print. PMID: 39616604.
• Allen MR, Wightman GP, Zhu Z, Poliak A, Smith DM, Dredze M, Ayers JW. Pharmacovigilance in the Age of Legalized Cannabis: Using Social Media to Monitor Drug-Drug Interactions Between Immunosuppressants and Cannabis-Derived Products. Drug Saf. 2025 Jan;48(1):99-105. doi: 10.1007/s40264-024-01481-x. Epub 2024 Sep 18. PMID: 39292423.

2023

• Smith DM, Schafer JR, Tullius B, Witkam L, Paust S. Natural killer cells for antiviral therapy. Sci Transl Med. 2023 Jan 4;15(677):eabl5278. doi: 10.1126/scitranslmed.abl5278. Epub 2023 Jan 4. Review. PubMed PMID: 36599006.
• Carlin AF, Clark AE, Chaillon A, Garretson AF, Bray W, Porrachia M, Santos AT, Rana TM, Smith DM. Virologic and Immunologic Characterization of Coronavirus Disease 2019 Recrudescence After Nirmatrelvir/Ritonavir Treatment. Clin Infect Dis. 2023 Feb 8;76(3):e530-e532. doi: 10.1093/cid/ciac496. PubMed PMID: 35723411; PubMed Central PMCID: PMC9278181.
• Gandhi RT, Bedimo R, Hoy JF, Landovitz RJ, Smith DM, Eaton EF, Lehmann C, Springer SA, Sax PE, Thompson MA, Benson CA, Buchbinder SP, Del Rio C, Eron JJ Jr, Günthard HF, Molina JM, Jacobsen DM, Saag MS. Antiretroviral Drugs for Treatment and Prevention of HIV Infection in Adults: 2022 Recommendations of the International Antiviral Society-USA Panel. JAMA. 2023 Jan 3;329(1):63-84. PMID: 36454551.
• Mitjà O, Reis G, Boulware DR, Spivak AM, Sarwar A, Johnston C, Webb B, Hill MD, Smith D, Kremsner P, Curran M, Carter D, Alexander J, Corbacho M, Lee TC, Hullsiek KH, McDonald EG, Hess R, Hughes M, Baeten JM, Schwartz I, Metz L, Richer L, Chew KW, Daar E, Wohl D, Dunne M. Hydroxychloroquine for treatment of non-hospitalized adults with COVID-19: A meta-analysis of individual participant data of randomized trials. Clin Transl Sci. 2023 Mar;16(3):524-535. Epub 2023 Jan 4. PMID: 36601684; PMCID: PMC10014689.
• Taiwo BO, Chew KW, Moser C, Wohl DA, Daar ES, Li JZ, Greninger AL, Bausch C, Luke T, Hoover K, Neytman G, Giganti MJ, Olefsky M, Javan AC, Fletcher CV, Eron JJ, Currier JS, Hughes MD, Smith DM; ACTIV-2/A5401 Study Team. Phase 2 safety and antiviral activity of SAB-185, a novel polyclonal antibody therapy for non-hospitalized adults with COVID-19. J Infect Dis. 2023 Jan 20:jiad013. Epub ahead of print. PMID: 36661240.
• Matza LS, Stewart KD, Naegeli AN, Mills KM, Coyne KS, Chew KW, Hughes MD, Smith DM. Qualitative interviews to evaluate content validity of the ACTIV-2 COVID-19 Symptom Diary (ACSD). J Patient Rep Outcomes. 2023 Jan 31;7(1):8. PMID: 36719546; PMCID: PMC9888338.
• Li Y, Harrison LJ, Chew KW, Currier JS, Wohl DA, Daar ES, Evering TH, Wu R, Giganti M, Ritz J, Javan AC, Coombs RW, Moser C, Hughes MD, Eron JJ, Smith DM, Li JZ. Nasal and Plasma Severe Acute Respiratory Syndrome Coronavirus 2 RNA Levels Are Associated With Timing of Symptom Resolution in the ACTIV-2 Trial of Nonhospitalized Adults With Coronavirus Disease 2019. Clin Infect Dis. 2023 Feb 18;76(4):734-737. PMID: 36210483; PMCID: PMC9619579.
• Mukim A, Smith DM, Deshmukh S, Qazi AA, Beliakova-Bethell N. A Camptothetin Analog, Topotecan, Promotes HIV Latency via Interference with HIV Transcription and RNA Splicing. J Virol. 2023 Feb 28;97(2):e0163022. doi: 10.1128/jvi.01630-22. Epub 2023 Jan 31. PMID: 36719238; PMCID: PMC9973035.
• Deo R, Choudhary MC, Moser C, Ritz J, Daar ES, Wohl DA, Greninger AL, Eron JJ, Currier JS, Hughes MD, Smith DM, Chew KW, Li JZ; ACTIV-2/A5401 Study Team. Symptom and Viral Rebound in Untreated SARS-CoV-2 Infection. Ann Intern Med. 2023 Mar;176(3):348-354. doi: 10.7326/M22-2381. Epub 2023 Feb 21. PMID: 36802755; PMCID: PMC10052317.
• Zhou P, Song G, Liu H, Yuan M, He WT, Beutler N, Zhu X, Tse LV, Martinez DR, Schäfer A, Anzanello F, Yong P, Peng L, Dueker K, Musharrafieh R, Callaghan S, Capozzola T, Limbo O, Parren M, Garcia E, Rawlings SA, Smith DM, Nemazee D, Jardine JG, Safonova Y, Briney B, Rogers TF, Wilson IA, Baric RS, Gralinski LE, Burton DR, Andrabi R. Broadly neutralizing anti-S2 antibodies protect against all three human betacoronaviruses that cause deadly disease. Immunity. 2023 Mar 14;56(3):669-686.e7. PMID: 36889306; PMCID: PMC9933850.
• Strathdee SA, Abramovitz D, Vera CF, Artamonova I, Patterson TL, Smith DM, Chaillon A, Bazzi AR. Predictors of COVID-19 vaccine uptake among people who inject drugs. Vaccine. 2023 Mar 17;41(12):1916-1924. PMID: 36697311; PMCID: PMC9868393.
• Carlin AF, Clark AE, Garretson AF, Bray W, Porrachia M, Santos AT, Rana TM, Chaillon A, Smith DM. Neutralizing Antibody Responses After Severe Acute Respiratory Syndrome Coronavirus 2 BA.2 and BA.2.12.1 Infection Do Not Neutralize BA.4 and BA.5 and Can Be Blunted by Nirmatrelvir/Ritonavir Treatment. Open Forum Infect Dis. 2023 Mar 21;10(4):ofad154. PMID: 37096144; PMCID: PMC10122487.
• Bender Ignacio RA, Chew KW, Moser C, Currier JS, Eron JJ, Javan AC, Giganti MJ, Aga E, Gibbs M, Tchouakam Kouekam H, Johnsson E, Esser MT, Hoover K, Neytman G, Newell M, Daar ES, Fischer W, Fletcher CV, Li JZ, Greninger AL, Coombs RW, Hughes MD, Smith D*, Wohl DA*; Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV)–2/A5401 Study Team. Safety and Efficacy of Combined Tixagevimab and Cilgavimab Administered Intramuscularly or Intravenously in Nonhospitalized Patients With COVID-19: 2 Randomized Clinical Trials. JAMA Netw Open. 2023 Apr 3;6(4):e2310039. PMID: 37099295; PMCID: PMC10134004.
• Thorlund K, Smith D, Linsell C, White N, Butler C, Boulware D, Currier J, Harari O, Lhomme E, Strub-Wourgaft N, Adam S, Mills E. The importance of appropriate selection of clinical endpoints in outpatient COVID-19 clinical trials. Commun Med (Lond). 2023 Apr 17;3(1):53. PMID: 37069219; PMCID: PMC10107578.
• Evering TH, Chew KW, Giganti MJ, Moser C, Pinilla M, Wohl DA, Currier JS, Eron JJ, Javan AC, Bender Ignacio R, Margolis D, Zhu Q, Ma J, Zhong L, Yan L, D’Andrea Nores U, Hoover K, Mocherla B, Choudhary MC, Deo R, Ritz J, Fischer WA, Fletcher CV, Li JZ, Hughes MD, Smith D*, Daar ES*; ACTIV-2/A5401 Study Team. Safety and Efficacy of Combination SARS-CoV-2 Neutralizing Monoclonal Antibodies Amubarvimab Plus Romlusevimab in Nonhospitalized Patients With COVID-19. Ann Intern Med. 2023 Apr 18:M22-3428. PMID: 37068272; PMCID: PMC10150320.
• Kanazawa J, Rawlings SA, Hendrickx S, Gianella S, Concha-Garcia S, Taylor J, Kaytes A, Patel H, Ndukwe S, Little SJ, Smith D, Dubé K. Lessons learned from the Last Gift study: ethical and practical challenges faced while conducting HIV cure-related research at the end of life. J Med Ethics. 2023 May;49(5):305-310. Epub 2022 Jun 22. PMID: 35732421; PMCID: PMC9772357.
• Ayers JW, Poliak A, Dredze M, Leas EC, Zhu Z, Kelley JB, Faix DJ, Goodman AM, Longhurst CA, Hogarth M, Smith DM. Comparing Physician and Artificial Intelligence Chatbot Responses to Patient Questions Posted to a Public Social Media Forum. JAMA Intern Med. 2023 Apr 28:e231838. PMID: 37115527; PMCID: PMC10148230.
• Dubé K, Villa TJ, Taylor J, Kaytes A, Moore DJ, Little SJ, Chaillon A, Smith DM, Gianella S. A Community-Driven Framework to Prioritize the Use of Donated Human Biological Materials in the Context of HIV Cure-Related Research at the End of Life. Pathog Immun. 2023 May 24;8(1):1-16. doi: 10.20411/pai.v8i1.583. PMID: 37252012; PMCID: PMC10225111.
• Dubé K, Shelton B, Patel H, Ndukwe SO, Concha-Garcia S, Dullano C, Solso S, Hendrickx S, Kaytes A, Taylor J, Villa TJ, Little SJ, Riggs PK, Lessard D, Arora AK, Costiniuk CT, Eskaf S, Smith DM, Gianella S. Perceived risks and benefits of enrolling people with HIV at the end of life in cure research in Southern California, United States. J Virus Erad. 2023 Jun 5;9(2):100328. doi: 10.1016/j.jve.2023.100328. PMID: 37440872; PMCID: PMC10334343.
• Rao E, Taylor J, Kaytes A, Concha-Garcia S, Riggs PK, Smith DM, Dubé K, Gianella S. Vulnerability in Biomedical Research: A Historical Reflection and Practical Implications for HIV Cure-Related Research. AIDS Res Hum Retroviruses. 2023 Jun 21. doi: 10.1089/AID.2022.0136. Epub ahead of print. PMID: 37227023.
• Ahuja SK, Manoharan MS, Lee GC, McKinnon LR, Meunier JA, Steri M, Harper N, Fiorillo E, Smith AM, Restrepo MI, Branum AP, Bottomley MJ, Orrù V, Jimenez F, Carrillo A, Pandranki L, Winter CA, Winter LA, Gaitan AA, Moreira AG, Walter EA, Silvestri G, King CL, Zheng YT, Zheng HY, Kimani J, Blake Ball T, Plummer FA, Fowke KR, Harden PN, Wood KJ, Ferris MT, Lund JM, Heise MT, Garrett N, Canady KR, Abdool Karim SS, Little SJ, Gianella S, Smith DM, Letendre S, Richman DD, Cucca F, Trinh H, Sanchez-Reilly S, Hecht JM, Cadena Zuluaga JA, Anzueto A, Pugh JA; South Texas Veterans Health Care System COVID-19 team; Agan BK, Root-Bernstein R, Clark RA, Okulicz JF, He W. Immune resilience despite inflammatory stress promotes longevity and favorable health outcomes including resistance to infection. Nat Commun. 2023 Jun 13;14(1):3286. doi: 10.1038/s41467-023-38238-6. PMID: 37311745; PMCID: PMC10264401.
• Ayers JW, Zhu Z, Poliak A, Leas EC, Dredze M, Hogarth M, Smith DM. Evaluating Artificial Intelligence Responses to Public Health Questions. JAMA Netw Open. 2023 Jun 1;6(6):e2317517. doi: 10.1001/jamanetworkopen.2023.17517. PMID: 37285160; PMCID: PMC10248742.
• Joyce C, Murrell S, Murrell B, Omorodion O, Ver LS, Carrico N, Bastidas R, Nedellec R, Bick M, Woehl J, Zhao F, Burns A, Barman S, Appel M, Ramos A, Wickramasinghe L, Eren K, Vollbrecht T, Smith DM, Kosakovsky Pond SL, McBride R, Worth C, Batista F, Sok D; IAVI Protocol C Investigators & The IAVI African HIV Research Network; Poignard P, Briney B, Wilson IA, Landais E, Burton DR. Antigen pressure from two founder viruses induces multiple insertions at a single antibody position to generate broadly neutralizing HIV antibodies. PLoS Pathog. 2023 Jun 29;19(6):e1011416. doi: 10.1371/journal.ppat.1011416. PMID: 37384622; PMCID: PMC10309625.
• Tang Y, Chaillon A, Gianella S, Wong LM, Li D, Simermeyer TL, Porrachia M, Ignacio C, Woodworth B, Zhong D, Du J, de la Parra Polina E, Kirchherr J, Allard B, Clohosey ML, Moeser M, Sondgeroth AL, Whitehill GD, Singh V, Dashti A, Smith DM, Eron JJ, Bar KJ, Chahroudi A, Joseph SB, Archin NM, Margolis DM, Jiang G. Brain microglia serve as a persistent HIV reservoir despite durable antiretroviral therapy. J Clin Invest. 2023 Jun 15;133(12):e167417. doi: 10.1172/JCI167417. PMID: 37317962; PMCID: PMC10266791.
• Jang H, Choudhury S, Yu Y, Sievers BL, Gelbart T, Singh H, Rawlings SA, Proal A, Tan GS, Qian Y, Smith D*, Freire M. Persistent immune and clotting dysfunction detected in saliva and blood plasma after COVID-19. Heliyon. 2023 Jul 4;9(7):e17958. doi: 10.1016/j.heliyon.2023.e17958. PMID: 37483779; PMCID: PMC10362241.
• Ayers JW, Zhu Z, Harrigian K, Wightman GP, Dredze M, Strathdee SA, Smith DM. Managing HIV During the COVID-19 Pandemic: A Study of Help-Seeking Behaviors on a Social Media Forum. AIDS Behav. 2023 Jul 21. doi: 10.1007/s10461-023-04134-9. Epub ahead of print. PMID: 37479919.
• Currier JS, Moser C, Eron JJ, Chew KW, Smith DM, Javan AC, Wohl DA, Daar ES, Hughes MD; ACTIV-2/A5401 Study Team. ACTIV-2: A Platform Trial for the Evaluation of Novel Therapeutics for the Treatment of Early COVID-19 in Outpatients. J Infect Dis. 2023 Aug 31;228(Suppl 2):S77-S82. doi: 10.1093/infdis/jiad246. PMID: 37650231; PMCID: PMC10469341.
• Chew KW, Moser C, Yeh E, Wohl DA, Daar ES, Ritz J, Javan AC, Eron JJ, Currier JS, Smith DM, Hughes MD; ACTIV-2/A5401 Study Team. Validity and Characterization of Time to Symptom Resolution Outcome Measures in the ACTIV-2/A5401 Outpatient COVID-19 Treatment Trial. J Infect Dis. 2023 Aug 31;228(Suppl 2):S83-S91. doi: 10.1093/infdis/jiad300. PMID: 37650237; PMCID: PMC10469584.
• Giganti MJ, Chew KW, Eron JJ, Li JZ, Pinilla M, Moser C, Javan AC, Fischer WA, Klekotka P, Margolis D, Wohl DA, Coombs RW, Daar ES, Smith DM, Currier JS, Hughes MD; ACTIV-2/A5401 Study Team. Association Between Anterior Nasal and Plasma SARS-CoV-2 RNA Levels and Hospitalization or Death in Nonhospitalized Adults With Mild-to-Moderate COVID-19. J Infect Dis. 2023 Aug 31;228(Suppl 2):S117-S125. doi: 10.1093/infdis/jiad287. PMID: 37650230; PMCID: PMC10469105.
• Moser CB, Chew KW, Giganti MJ, Li JZ, Aga E, Ritz J, Greninger AL, Javan AC, Daar ES, Currier JS, Eron JJ, Smith DM, Hughes MD. Statistical Challenges when Analyzing SARS-CoV-2 RNA Measurements Below the Assay Limit of Quantification in COVID-19 Clinical Trials. medRxiv [Preprint]. 2023 Mar 17:2023.03.13.23287208. doi: 10.1101/2023.03.13.23287208. Update in: J Infect Dis. 2023 Aug 31;228(Suppl 2):S101-S110. doi: 10.1093/infdis/jiad285. PMID: 36993419; PMCID: PMC10055451.
• Li Y, Moser C, Aga E, Currier JS, Wohl DA, Daar ES, Ritz J, Greninger AL, Sieg S, Parikh UM, Coombs RW, Hughes MD, Eron JJ, Smith DM, Chew KW, Li JZ; ACTIV-2/A5401 Study Team. Immune Status and SARS-CoV-2 Viral Dynamics. J Infect Dis. 2023 Aug 31;228(Suppl 2):S111-S116. doi: 10.1093/infdis/jiad200. PMID: 37650232; PMCID: PMC10469582.
• Ribeiro RM, Choudhary MC, Deo R, Giganti MJ, Moser C, Ritz J, Greninger AL, Regan J, Flynn JP, Wohl DA, Currier JS, Eron JJ, Hughes MD, Smith DM, Chew KW, Daar ES, Perelson AS, Li JZ; ACTIV-2/A5401 Study Team. Variant-Specific Viral Kinetics in Acute COVID-19. J Infect Dis. 2023 Aug 31;228(Suppl 2):S136-S143. doi: 10.1093/infdis/jiad314. PMID: 37650233; PMCID: PMC10469346.
• Moser CB, Chew KW, Ritz J, Newell M, Javan AC, Eron JJ, Daar ES, Wohl DA, Currier JS, Smith DM*, Hughes MD*; ACTIV-2/A5401 Study Team. Pooling Different Placebos as a Control Group in a Randomized Platform Trial: Benefits and Challenges From Experience in the ACTIV-2 COVID-19 Trial. J Infect Dis. 2023 Aug 31;228(Suppl 2):S92-S100. doi: 10.1093/infdis/jiad209. PMID: 37650234; PMCID: PMC10686688.
• Moser CB, Chew KW, Giganti MJ, Li JZ, Aga E, Ritz J, Greninger AL, Javan AC, Bender Ignacio R, Daar ES, Wohl DA, Currier JS, Eron JJ, Smith DM*, Hughes MD*; ACTIV-2/A5401 Study Team. Statistical Challenges When Analyzing SARS-CoV-2 RNA Measurements Below the Assay Limit of Quantification in COVID-19 Clinical Trials. J Infect Dis. 2023 Aug 31;228(Suppl 2):S101-S110. doi: 10.1093/infdis/jiad285. PMID: 37650235; PMCID: PMC10469328.
• Evering TH, Moser CB, Jilg N, Yeh E, Sanusi B, Wohl DA, Daar ES, Li JZ, Klekotka P, Javan AC, Eron JJ, Currier JS, Hughes MD, Smith DM*, Chew KW*; ACTIV-2/A5401 Study Team. Long COVID After Bamlanivimab Treatment. J Infect Dis. 2023 Aug 31;228(Suppl 2):S126-S135. doi: 10.1093/infdis/jiad286. PMID: 37650236; PMCID: PMC10686694.
• Ayers JW, Goodman AM, Smith DM. #MedEd: Medical Education and Knowledge Translation on Social Media. JAMA. 2023 Sep 12;330(10):909-910. doi: 10.1001/jama.2023.12465. PMID: 37642959.
• Clark AE, Furst A, Sejane K, Stellwagen L, Proost M, Pride D, Smith DM, Carlin AF, Bode L. Validating Tools to Detect and Inactivate Monkeypox Virus in Human Milk. Breastfeed Med. 2023 Oct;18(10):785-789. doi: 10.1089/bfm.2023.0175. Epub 2023 Sep 21. PMID: 37733262; PMCID: PMC10616931.
• Jilg N, Chew KW, Giganti MJ, Daar ES, Wohl DA, Javan AC, Kantor A, Moser C, Coombs RW, Neytman G, Hoover K, Jana A, Hart PA, Greninger AL, Szurgot B, Eron JJ, Currier JS, Hughes MD, Smith DM*, Li JZ*; ACTIV-2/A5401 Study Team. One Week of Oral Camostat Versus Placebo in Nonhospitalized Adults With Mild-to-Moderate Coronavirus Disease 2019: A Randomized Controlled Phase 2 Trial. Clin Infect Dis. 2023 Oct 5;77(7):941-949. doi: 10.1093/cid/ciad342. PMID: 37279602; PMCID: PMC10552586.
• Goyal R, De Gruttola V, Gianella S, Caballero G, Porrachia M, Ignacio C, Woodworth B, Smith DM, Chaillon A. Identification of system-level features in HIV migration within a host. PLoS One. 2023 Sep 26;18(9):e0291367. doi: 10.1371/journal.pone.0291367. PMID: 37751407; PMCID: PMC10521982.
• Ayers JW, Dredze M, Smith DM. Machine-Made Empathy? Why Medicine Still Needs Humans-Reply. JAMA Intern Med. 2023 Nov 1;183(11):1279-1280. doi: 10.1001/jamainternmed.2023.4392. PMID: 37695627.
• Jagannathan P, Chew KW, Giganti MJ, Hughes MD, Moser C, Main MJ, Monk PD, Javan AC, Li JZ, Fletcher CV, McCarthy C, Wohl DA, Daar ES, Eron JJ, Currier JS, Singh U, Smith DM, Fischer W; ACTIV-2/A5401 Study Team. Safety and efficacy of inhaled interferon-β1a (SNG001) in adults with mild-to-moderate COVID-19: a randomized, controlled, phase II trial. EClinicalMedicine. 2023 Oct 6;65:102250. doi: 10.1016/j.eclinm.2023.102250. PMID: 37855026; PMCID: PMC10579289.
• Lyons DE, Kumar P, Roan NR, Defechereux PA, Feschotte C, Lange UC, Murthy N, Sameshima P, Verdin E, Ake JA, Parsons MS, Nath A, Gianella S, Smith DM, Kallas EG, Villa TJ, Strange R, Mwesigwa B, Furler O’Brien RL, Nixon DF, Ndhlovu LC, Valente ST, Ott M. HIV-1 Remission: Accelerating the Path to Permanent HIV-1 Silencing. Viruses. 2023 Oct 28;15(11):2171. doi: 10.3390/v15112171. PMID: 38005849; PMCID: PMC10674359.
• Huang DQ, Ajmera V, Tomaszewski C, LaFree A, Bettencourt R, Thompson WK, Smith DM, Malhotra A, Mehta RL, Tolia V, Yin J, Insel PA, Leachman S, Jung J, Collier S, Richards L, Woods K, Amangurbanova M, Bhatt A, Zhang X, Penciu OM, Zarich S, Retta T, Harkins MS, Teixeira JP, Chinnock B, Utay NS, Lake JE, Loomba R. Ramipril for the Treatment of COVID-19: RAMIC, a Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Adv Ther. 2023 Nov;40(11):4805-4816. doi: 10.1007/s12325-023-02618-7. Epub 2023 Aug 24. PMID: 37615850; PMCID: PMC10709987.

2022

• Davey M. Smith, Jolie R. Schafer, Brian Tullius, Laura Witkam, Silke Paust. NK cells for antiviral therapy. Sci Transl Med. In press. 2022.
• Choudhary MC, Chew KW, Deo R, Flynn JP, Regan J, Crain CR, Moser C, Hughes MD, Ritz J, Ribeiro RM, Ke R, Dragavon JA, Javan AC, Nirula A, Klekotka P, Greninger AL, Fletcher CV, Daar ES, Wohl DA, Eron JJ, Currier JS, Parikh UM, Sieg SF, Perelson AS, Coombs RW, Smith DM, Li JZ. Emergence of SARS-CoV-2 escape mutations during Bamlanivimab therapy in a phase II randomized clinical trial. Nat Microbiol. 2022 Nov;7(11):1906-1917. doi: 10.1038/s41564-022-01254-1. Epub 2022 Oct 26. PubMed PMID: 36289399; PubMed Central PMCID: PMC9675946.
• Riggs PK, Chaillon A, Jiang G, Letendre SL, Tang Y, Taylor J, Kaytes A, Smith DM, Dubé K, Gianella S. Lessons for Understanding Central Nervous System HIV Reservoirs from the Last Gift Program. Curr HIV/AIDS Rep. 2022 Oct 19:1–14. doi: 10.1007/s11904-022-00628-8. Epub ahead of print. PMID: 36260191; PMCID: PMC9580451.
• Smith DM, Li JZ, Moser C, Yeh E, Currier JS, Chew KW, Hughes MD; ACTIV-2/A5401 Study Team. Recurrence of Symptoms Following a 2-Day Symptom Free Period in Patients With COVID-19. JAMA Netw Open. 2022 Oct 3;5(10):e2238867. doi: 10.1001/jamanetworkopen.2022.38867. PMID: 36301549; PMCID: PMC9614575.
• Deo R, Choudhary MC, Moser C, Ritz J, Daar ES, Wohl DA, Greninger AL, Eron JJ, Currier JS, Hughes MD, Smith DM, Chew KW, Li JZ; ACTIV-2/A5401 Study Team. Viral and Symptom Rebound in Untreated COVID-19 Infection. medRxiv [Preprint]. 2022 Aug 2:2022.08.01.22278278. doi: 10.1101/2022.08.01.22278278. PMID: 35982660; PMCID: PMC9387151.
• Mehta SR, Smith DM, Boukadida C, Chaillon A. Comparative Dynamics of Delta and Omicron SARS-CoV-2 Variants across and between California and Mexico. Viruses. 2022 Jul 8;14(7):1494. doi: 10.3390/v14071494. PMID: 35891473; PMCID: PMC9317407.
• Boucau J, Chew KW, Choudhary M, Deo R, Regan J, Flynn JP, Crain CR, Hughes MD, Ritz J, Moser C, Dragavon JA, Javan AC, Nirula A, Klekotka P, Greninger AL, Coombs RW, Fischer WA 2nd, Daar ES, Wohl DA, Eron JJ, Currier JS, Smith DM, Li JZ, Barczak AK; ACTIV-2/A5401 Study Team. Monoclonal antibody treatment drives rapid culture conversion in SARS-CoV-2 infection. medRxiv [Preprint]. 2021 Dec 30:2021.12.25.21268211. Update in: Cell Rep Med. 2022 Jun 20;:100678. PMID: 35018382; PMCID: PMC8750705.
• Shapiro AE, Bender Ignacio RA, Whitney BM, Delaney JA, Nance RM, Bamford L, Wooten D, Keruly JC, Burkholder G, Napravnik S, Mayer KH, Webel AR, Kim HN, Van Rompaey SE, Christopoulos K, Jacobson J, Karris M, Smith D, Johnson MO, Willig A, Eron JJ, Hunt P, Moore RD, Saag MS, Mathews WC, Crane HM, Cachay ER, Kitahata MM; CFAR Network of Integrated Clinical Systems. Factors Associated With Severity of COVID-19 Disease in a Multicenter Cohort of People With HIV in the United States, March-December 2020. J Acquir Immune Defic Syndr. 2022 Aug 1;90(4):369-376. doi: 10.1097/QAI.0000000000002989. PMID: 35364600.
• Lessard D, Dubé K, Bilodeau M, Keeler P, Margolese S, Rosenes R, Sinyavskaya L, Durand M, Benko E, Kovacs C, Guerlotté C, Tharao W, Arnold K, Masching R, Taylor D, Sousa J, Ostrowski M, Taylor J, Kaytes A, Smith D, Gianella S, Chomont N, Angel JB, Routy JP, Cohen ÉA, Lebouché B, Costiniuk CT. Willingness of Older Canadians with HIV to Participate in HIV Cure Research Near and After the End of Life: A Mixed-Method Study. AIDS Res Hum Retroviruses. 2022 Aug;38(8):670-682. doi: 10.1089/AID.2022.0006. Epub 2022 Jul 28. PMID: 35778845.
• Birabaharan M, Kaelber DC, Pettus JH, Smith DM. Risk of new-onset type 2 diabetes in 600 055 people after COVID-19: A cohort study. Diabetes Obes Metab. 2022 Jun;24(6):1176-1179. doi: 10.1111/dom.14659. Epub 2022 Feb 15. PMID: 35112782; PMCID: PMC9035030.
• Kanazawa J, Rawlings SA, Hendrickx S, Gianella S, Concha-Garcia S, Taylor J, Kaytes A, Patel H, Ndukwe S, Little SJ, Smith D, Dubé K. Lessons learned from the Last Gift study: ethical and practical challenges faced while conducting HIV cure-related research at the end of life. J Med Ethics. 2022 Jun 22:medethics-2021-107512. Epub ahead of print. PMID: 35732421.
• Ding X, Chaillon A, Pan X, Zhang J, Zhong P, He L, Chen W, Fan Q, Jiang J, Luo M, Xia Y, Guo Z, Smith DM. Characterizing genetic transmission networks among newly diagnosed HIV-1 infected individuals in eastern China: 2012-2016. PLoS One. 2022 Jun 16;17(6):e0269973. PMID: 35709166; PMCID: PMC9202869.
• Carlin AF, Clark AE, Chaillon A, Garretson AF, Bray W, Porrachia M, Santos AT, Rana TM, Smith DM. Virologic and Immunologic Characterization of COVID-19 Recrudescence after Nirmatrelvir/Ritonavir Treatment. Clin Infect Dis. 2022 Jun 20:ciac496. doi: 10.1093/cid/ciac496. Epub ahead of print. PMID: 35723411; PMCID: PMC9278181.
• He WT, Musharrafieh R, Song G, Dueker K, Tse LV, Martinez DR, Schäfer A, Callaghan S, Yong P, Beutler N, Torres JL, Volk RM, Zhou P, Yuan M, Liu H, Anzanello F, Capozzola T, Parren M, Garcia E, Rawlings SA, Smith DM, Wilson IA, Safonova Y, Ward AB, Rogers TF, Baric RS, Gralinski LE, Burton DR, Andrabi R. Targeted isolation of diverse human protective broadly neutralizing antibodies against SARS-like viruses. Nat Immunol. 2022 Jun;23(6):960-970. doi: 10.1038/s41590-022-01222-1. Epub 2022 Jun 2. PMID: 35654851.
• Wang C, Schlub TE, Yu WH, Tan CS, Stefic K, Gianella S, Smith DM, Lauffenburger DA, Chaillon A, Julg B. Landscape of Human Immunodeficiency Virus Neutralization Susceptibilities Across Tissue Reservoirs. Clin Infect Dis. 2022 Oct 12;75(8):1342-1350. doi: 10.1093/cid/ciac164. PMID: 35234862.
• Pusterla N, Chaillon A, Ignacio C, Smith DM, Barnum S, Lawton KOY, Smith G, Pickering B. SARS-CoV-2 Seroconversion in an Adult Horse with Direct Contact to a COVID-19 Individual. Viruses. 2022 May 14;14(5):1047. doi: 10.3390/v14051047. PMID: 35632788.
• Carlin AF, Clark AE, Chaillon A, Garretson AF, Bray W, Porrachi M, Santos AT, Smith DM. Virologic and Immunologic Characterization of COVID-19 Recrudescence after Nirmatrelvir/Ritonavir Treatment. Res Sq [Preprint]. 2022 May 18:rs.3.rs-1662783. doi: 10.21203/rs.3.rs-1662783/v1. Update in: Clin Infect Dis. 2022 Jun 20;: PMID: 35611335; PMCID: PMC9128786.
• Birabaharan M, Strunk A, Kaelber DC, Smith DM, Martin TCS. Sex differences in type 2 diabetes mellitus prevalence among persons with HIV. AIDS. 2022 Mar 1;36(3):383-389. doi: 10.1097/QAD.0000000000003127. PMID: 34750292; PMCID: PMC8795484.
• Zhou P, Yuan M, Song G, Beutler N, Shaabani N, Huang D, He WT, Zhu X, Callaghan S, Yong P, Anzanello F, Peng L, Ricketts J, Parren M, Garcia E, Rawlings SA, Smith DM, Nemazee D, Teijaro JR, Rogers TF, Wilson IA, Burton DR, Andrabi R. A human antibody reveals a conserved site on beta-coronavirus spike proteins and confers protection against SARS-CoV-2 infection. Sci Transl Med. 2022 Mar 23;14(637):eabi9215. doi: 10.1126/scitranslmed.abi9215. Epub 2022 Mar 23. PMID: 35133175.
• Yu ED, Wang E, Garrigan E, Goodwin B, Sutherland A, Tarke A, Chang J, Gálvez RI, Mateus J, Ramirez SI, Rawlings SA, Smith DM, Filaci G, Frazier A, Weiskopf D, Dan JM, Crotty S, Grifoni A, Sette A, da Silva Antunes R. Development of a T cell-based immunodiagnostic system to effectively distinguish SARS-CoV-2 infection and COVID-19 vaccination status. Cell Host Microbe. 2022;30(3):388-99.e3. Epub 20220208. doi: 10.1016/j.chom.2022.02.003. PubMed PMID: 35172129.
• Moser C, Li JZ, Eron JJ, Aga E, Daar ES, Wohl DA, Coombs RW, Javan AC, Bender Ignacio RA, Jagannathan P, Ritz J, Sieg SF, Parikh UM, Hughes MD, Currier JS, Smith DM*, Chew KW*; ACTIV-2/A5401 Study Team. Predictors of SARS-CoV-2 RNA From Nasopharyngeal Swabs and Concordance With Other Compartments in Nonhospitalized Adults With Mild to Moderate COVID-19. Open Forum Infect Dis. 2022 Nov 11;9(11):ofac618. doi: 10.1093/ofid/ofac618. PMID: 36467293; PMCID: PMC9709705.

2021

• He WT, Musharrafieh R, Song G, Dueker K, Tse LV, Martinez DR, Schäfer A, Callaghan S, Yong P, Beutler N, Torres JL, Volk RM, Zhou P, Yuan M, Liu H, Anzanello F, Capozzola T, Parren M, Garcia E, Rawlings SA, Smith DM, Wilson IA, Safonova Y, Ward AB, Rogers TF, Baric RS, Gralinski LE, Burton DR, Andrabi R. Targeted isolation of panels of diverse human protective broadly neutralizing antibodies against SARS-like viruses. bioRxiv [Preprint]. 2022 Feb 8:2021.09.08.459480. doi: 10.1101/2021.09.08.459480. Update in: Nat Immunol. 2022 Jun;23(6):960-970. PMID: 35169804.
• Dubé K, Kanazawa J, Dee L, Taylor J, Sauceda JA, Gianella S, Smith D, Deeks SG, Peluso MJ. Considerations for designing and implementing combination HIV cure trials: findings from a qualitative in-depth interview study in the United States. AIDS Res Ther. 2021;18(1):75. Epub 20211018. PubMed PMID: 34663375.
• Huff S, Kummetha IR, Tiwari SK, Huante MB, Clark AE, Wang S, Bray W, Smith D, Carlin AF, Endsley M, Rana TM. Discovery and Mechanism of SARS-CoV-2 Main Protease Inhibitors. J Med Chem. 2021. Epub 20210927. PubMed PMID: 34570513.
• Kanazawa J, Gianella S, Concha-Garcia S, Taylor J, Kaytes A, Christensen C, Patel H, Ndukwe S, Rawlings S, Hendrickx S, Little S, Brown B, Smith D, Dubé K. Ethical and practical considerations for interventional HIV cure-related research at the end-of-life: A qualitative study with key stakeholders in the United States. PLoS One. 2021;16(7):e0254148. PubMed PMID: 34270612.
• Rawlings SA, Chaillon A, Smith D, Gianella S. Scale up rapid research autopsies for tissue immunology. Nature. 2021;595(7867):352. PubMed PMID: 34257439.
• Zhang T, Gupta A, Frederick D, Layman L, Smith DM, Gianella S, Kieffer C. 3D Visualization of Immune Cell Populations in HIV-Infected Tissues via Clearing, Immunostaining, Confocal, and Light Sheet Fluorescence Microscopy. J Vis Exp. 2021(171):e62441. PubMed PMID: 34028448.
• Javadi SS, Mathur K, Concha-Garcia S, Patel H, Perry KE, Lo M, Taylor J, Kaytes A, Little S, Gianella S, Smith D, Dubé K. Attitudes and perceptions of next-of-kin/loved ones toward end-of-life HIV cure-related research: A qualitative focus group study in Southern California. PLoS One. 2021 May 7;16(5):e0250882. doi: 10.1371/journal.pone.0250882. PMID: PMCID: PMC8104928.
• Tarke A, Sidney J, Methot N, Yu ED, Zhang Y, Dan JM, Goodwin B, Rubiro P, Sutherland A, Wang E, Frazier A, Ramirez SI, Rawlings SA, Smith DM, da Silva Antunes R, Peters B, Scheuermann RH, Weiskopf D, Crotty S, Grifoni A, Sette A. Impact of SARS-CoV-2 variants on the total CD4(+) and CD8(+) T cell reactivity in infected or vaccinated individuals. Cell Rep Med. 2021:100355. PubMed PMID: 34230917.
• Rawlings SA, Scott B, Layman L, Naranatt P, Heltsley R, Ignacio C, Porrachia M, Gianella S, Smith D, Chaillon A. Can’t Work From Home: Pooled Nucleic Acid Testing of Laboratory Workers During the COVID-19 Pandemic. Open Forum Infect Dis. 2021;8(7):ofab129. doi: 10.1093/ofid/ofab129. PubMed PMID: 34327248.
• Song G, He WT, Callaghan S, Anzanello F, Huang D, Ricketts J, Torres JL, Beutler N, Peng L, Vargas S, Cassell J, Parren M, Yang L, Ignacio C, Smith DM, Voss JE, Nemazee D, Ward AB, Rogers T, Burton DR, Andrabi R. Cross-reactive serum and memory B cell responses to spike protein in SARS-CoV-2 and endemic coronavirus infection. Nature. 2021 doi: 10.1101/2020.09.22.308965. PubMed PMID: 32995770.
• Chaillon A, Smith DM. Phylogenetic analyses of SARS-CoV-2 B.1.1.7 lineage suggest a single origin followed by multiple exportation events versus convergent evolution. Clin Infect Dis. 2021. Epub 2021/03/28. doi: 10.1093/cid/ciab265. PubMed PMID: 33772259.
• Gallardo CM, Wang S, Montiel-Garcia DJ, Little SJ, Smith DM, Routh AL, Torbett BE. MrHAMER yields highly accurate single molecule viral sequences enabling analysis of intra-host evolution. Nucleic Acids Res. 2021:2021.01.27.428469. Epub 2021/04/14. doi: 10.1093/nar/gkab231. PubMed PMID: 33849057.
• Little SJ, Chen T, Wang R, Anderson C, Kosakovsky Pond S, Nakazawa M, Mathews WC, DeGruttola V, Smith DM. Effective HIV Molecular Surveillance Requires Identification of Incident Cases of Infection. Clin Infect Dis. 2021. Epub 2021/02/16. doi: 10.1093/cid/ciab140. PubMed PMID: 33588434.
• Ajmera V, Thompson WK, Smith DM, Malhotra A, Mehta RL, Tolia V, Yin J, Sriram K, Insel PA, Collier S, Richards L, Loomba R. RAMIC: Design of a randomized, double-blind, placebo-controlled trial to evaluate the efficacy of ramipril in patients with COVID-19. Contemp Clin Trials. 2021;103:106330. Epub 2021/02/26. doi: 10.1016/j.cct.2021.106330. PubMed PMID: 33631357.
• Tarke A, Sidney J, Kidd CK, Dan JM, Ramirez SI, Yu ED, Mateus J, da Silva Antunes R, Moore E, Rubiro P, Methot N, Phillips E, Mallal S, Frazier A, Rawlings SA, Greenbaum JA, Peters B, Smith DM, Crotty S, Weiskopf D, Grifoni A, Sette A. Comprehensive analysis of T cell immunodominance and immunoprevalence of SARS-CoV-2 epitopes in COVID-19 cases. Cell Rep Med. 2021 Feb 16;2(2):100204. doi: 10.1016/j.xcrm.2021.100204. Epub 2021 Jan 26. PMID: 33521695.
• Dan JM, Mateus J, Kato Y, Hastie KM, Yu ED, Faliti CE, Grifoni A, Ramirez SI, Haupt S, Frazier A, Nakao C, Rayaprolu V, Rawlings SA, Peters B, Krammer F, Simon V, Saphire EO, Smith DM, Weiskopf D, Sette A, Crotty S. Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection. Science. 2021. Epub 2021/01/08. doi: 10.1126/science.abf4063. PubMed PMID: 33408181.
• Moshiri N, Smith DM, Mirarab S. HIV Care Prioritization using Phylogenetic Branch Length. J Acquir Immune Defic Syndr. 2020;Publish Ahead of Print. Epub 2021/01/05. doi: 10.1097/qai.0000000000002612. PubMed PMID: 33394616.